Impact of the revised WHO classification of diffuse low-grade glioma on clinical decision making: A case report

Background: In the 2016 update of the World Health Organization Classification of Tumors of the central nervous system, phenotypic and genotypic parameters are integrated in diffuse low-grade glioma (LGG) tumor classification. Implementation of this combined phenotypic-genotypic characterization ide...

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Published inSurgical neurology international Vol. 8; no. 1; p. 223
Main Authors van der Vlis, Tim, Hoeben, Ann, Beckervordersandforth, Jan, Ackermans, Linda, Eekers, Daniëlle, Wennekes, Rianne, Schijns, Olaf
Format Journal Article
LanguageEnglish
Published United States Wolters Kluwer India Pvt. Ltd 01.01.2017
Medknow Publications & Media Pvt Ltd
Subjects
Neuro-Oncology: Case Report
treatment
WHO classification
molecular characteristics
Low-grade glioma
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Summary:Background: In the 2016 update of the World Health Organization Classification of Tumors of the central nervous system, phenotypic and genotypic parameters are integrated in diffuse low-grade glioma (LGG) tumor classification. Implementation of this combined phenotypic-genotypic characterization identifies prognostic relevant subgroups. Case Description: We report a case of a 67-year-old patient with an LGG that showed molecular characteristics similar to glioblastoma multiforme (GBM). After gross total tumor resection, the patient received combination therapy (radiotherapy and chemotherapy) according to high-grade glioma treatment protocol. Conclusion: The introduction of molecular parameters to the classification of LGG will add a level of objectivity, which will yield biological homogeneous subclasses. Consequently, this will influence patient counseling and clinical decision making regarding treatment protocols.
ISSN:2152-7806
2229-5097
2152-7806
DOI:10.4103/sni.sni_166_17