The m6A‑methylase complex and mRNA export

During synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which stimulates the nuclear export of mature mRNAs...

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Published inBiochimica et biophysica acta. Gene regulatory mechanisms Vol. 1862; no. 3; pp. 319 - 328
Main Authors Lesbirel, Simon, Wilson, Stuart A.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.03.2019
Elsevier
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Summary:During synthesis, mRNA undergoes a number of modifications such as capping, splicing and polyadenylation. These processes are coupled with the orderly deposition of the TREX complex on the mRNA and subsequent recruitment of the NXF1-P15 heterodimer which stimulates the nuclear export of mature mRNAs. mRNAs also undergo a number of internal modifications, the most common of which is the N6‑methyladenosine (m6A) modification. In this review we discuss the recent evidence of coupling between the m6A modification, RNA processing and export. •mRNA processing and export are coupled with the N6‑methyladenosine (m6A) modification of mRNA.•TREX and SR proteins cooperate with m6A writers and readers in mRNA export.•Ultimately the m6A modification leads to NXF1 recruitment and mRNA export
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Present address: The Jackson Laboratory, 600 Main Street, Bar Harbour, ME USA 04609.
ISSN:1874-9399
1876-4320
1876-4320
DOI:10.1016/j.bbagrm.2018.09.008