Ultrasonographic Evaluation of Nail Involvement in Patients With Axial Spondyloarthritis

• Published in: Journal of ultrasound in medicine Vol. 43; no. 5; pp. 967 - 978
• Main Authors: Kulaksız, Bilal, Palamar, Deniz, Misirlioglu, Tugce Ozekli, Akgun, Kenan, Terlemez, Rana
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.05.2024
• Subjects: axial spondyloarthritis; nail; psoriatic arthritis; ultrasonography; psoriatic arthritis; nail; ultrasonography; axial spondyloarthritis
• ISSN: 0278-4297; 1550-9613
• DOI: 10.1002/jum.16426

Objectives This study aimed to evaluate the nail units of patients with axial spondyloarthritis (ax‐SpA) using ultrasound and to identify any subclinical changes. We also aimed to examine the relationship between clinical enthesitis scores and nail involvement in patients with ax‐SpA. Methods The study included 40 patients with ax‐Spa, 40 patients with psoriatic arthritis (PsA), and 40 healthy controls. The thickness of the nail plates, morphological changes, the thickness of the proximal nail units, the thickness of the nail beds, and power Doppler signal intensities were evaluated and compared. Maastricht Ankylosing Spondylitis Enthesitis Score and Spondyloarthritis Research Consortium of Canada Enthesitis Index were also evaluated in patients with ax‐SpA. Results There was no significant difference between the thickness of the nail plates of the three groups (P > .05). The first nail bed thickness of ax‐SpA cases was significantly higher than the control group (P = .046), and the fourth and fifth nail proximal unit thicknesses of the control group were significantly lower than the ax‐SpA and PsA groups (P = .023, P = .017). We also found that the Wortsman scores of the cases with PsA were significantly higher than the ax‐SpA and control groups (P = .0001). Conclusion The thickness of the proximal nail unit adjacent to the insertion of the digital extensor tendon, which is considered as the enthesis area, is similar to the patients with PsA in patients with ax‐SpA, especially in the fourth and fifth fingers compared to the control group. On the other hand, almost no structural changes in nail plates were observed in patients with ax‐SpA group.