Modified Approach for Establishing Filament-induced Permanent Middle Cerebral Artery Occlusion Rats and Mice Models

BRAIN ischemia stroke is with more than 10% a devastating disease, stroke patients either severely disabled or dead. Although rodent filament middle cerebral artery occlusion （MCAO）model can mimic human brain ischemic stroke well, its wide use was restricted by difficulty in surgery, especially in l...

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Published inChinese medical sciences journal Vol. 26; no. 4; pp. 257 - 258
Main Authors Ji, You-xin, Lan, Ke-tao, Geng, Chuan-xin, Zou, Xiao, Wang, Song-ping
Format Journal Article
LanguageEnglish
Published China Elsevier B.V 01.12.2011
Department of Medical Oncology, Qingdao Central Hospital, Second Affiliated Hospital of Qingdao University, Qingdao 266042, China
Subjects
Animals
Disease Models, Animal
Infarction, Middle Cerebral Artery - etiology
Male
Mice
Mice, Inbred C57BL
Rats
Rats, Sprague-Dawley
SD大鼠
动脉
大脑
小鼠模型
永久性
立方
纤维
闭塞
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Summary:BRAIN ischemia stroke is with more than 10% a devastating disease, stroke patients either severely disabled or dead. Although rodent filament middle cerebral artery occlusion （MCAO）model can mimic human brain ischemic stroke well, its wide use was restricted by difficulty in surgery, especially in ligating pterygopalatine artery （PPA）. Twenty-seven male Sprague-Dawley rats were randomly divided into A, B, C groups （n=9）. All the rats were performed MCAO surgery with sutures of difference sizes. Group A used 4-0 blocking suture plus ipsilateral PPA block, group B used 3-0 blocking suture plus ipsilateral common carotid artery （CCA） block,
Bibliography:BRAIN ischemia stroke is with more than 10% a devastating disease, stroke patients either severely disabled or dead. Although rodent filament middle cerebral artery occlusion （MCAO）model can mimic human brain ischemic stroke well, its wide use was restricted by difficulty in surgery, especially in ligating pterygopalatine artery （PPA）. Twenty-seven male Sprague-Dawley rats were randomly divided into A, B, C groups （n=9）. All the rats were performed MCAO surgery with sutures of difference sizes. Group A used 4-0 blocking suture plus ipsilateral PPA block, group B used 3-0 blocking suture plus ipsilateral common carotid artery （CCA） block
11-2752/R
ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1001-9294
DOI:10.1016/S1001-9294(12)60013-3