Immunohistochemical analysis of tissue remodelling during the anagen-catagen transition of the human hair follicle
Summary The transition from the growth phase (anagen) to the involution phase (catagen) involves profound morphological changes in the human hair follicle. Club hair and epithelial column formation, for example, are key features of the catagen phase, which result in the disruption of physical intera...
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Published in | British journal of dermatology (1951) Vol. 137; no. 1; pp. 31 - 38 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.07.1997
Blackwell |
Subjects | |
Online Access | Get full text |
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Summary: | Summary
The transition from the growth phase (anagen) to the involution phase (catagen) involves profound morphological changes in the human hair follicle. Club hair and epithelial column formation, for example, are key features of the catagen phase, which result in the disruption of physical interaction between the bulb and the dermal papilla. However, the dynamics and tissue remodelling that occur during this involution process remain largely unknown. Using monoclonal antibodies directed against K14 keratin, trichohyalin, transglutaminase I, desmoglein and Ki67 antigen, we followed the movements of each of the main hair follicle compartments during the onset of catagen. Our results indicate that the inner root sheath is an early target in this process, suggesting a key role for this compartment in the maintenance of hair follicle homeostasis. |
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Bibliography: | ArticleID:BJD31 ark:/67375/WNG-XL2HKZL4-P istex:7D7EA051E5957B2F8FAA81D4320455EDAEA8368E ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0007-0963 1365-2133 |
DOI: | 10.1046/j.1365-2133.1997.17641854.x |