MODERN ANTICEPTIC HYDROGEL IN TREATMENT OF INFECTIOUS COMPLICATIONS OF WOUNDS IN SURGERY

• Published in: Vestnik hirurgii im. I.I. Grekova Vol. 175; no. 3; pp. 26 - 31
• Main Authors: Afinogenov, G E, Afinogenova, A G, Maday, D Yu, Krylov, K M, Krylov, P K, Biktinirov, E E, Maday, O D
• Format: Journal Article
• Language: English; Russian
• Published: Russia (Federation) Pavlov First Saint Petersburg State Medical University 2016
• Subjects: Animals; Anti-Infective Agents, Local - pharmacology; anticeptics; Bandages, Hydrocolloid; Humans; hydrogels; Male; Microbial Sensitivity Tests - methods; Microbiota - drug effects; purulent infection; Rats; Surgical Wound Infection - prevention & control; Treatment Outcome; Wound Healing - drug effects; Wound Healing - physiology; Wound Infection - etiology; Wound Infection - microbiology; Wound Infection - therapy
• ISSN: 0042-4625; 2686-7370
• DOI: 10.24884/0042-4625-2016-175-3-26-31

Treatment and prevention of infectious complications remain the actual problems of surgery. Purulent complications very often arise in operative interventions with an application of various fixing devices. A study of the adhesive surgical antiseptic (ASA) «ARGAKOL» (Registration certificate № FS 012б2005/1878-05) was completed. The results of the preliminary antimicrobial activity of the developed composition showed that ASA «ARGAKOL» had a broad spectrum of antimicrobial action. There was used the method of twofold serial dilutions in a liquid medium and Cup-suspension. The study of the influence of the ASA «ARGAKOL» on the wound healing was made in the experiment on white outbred rats. There were carried out two series of experiments with 10 rats in each group: on the model of just contaminated wound (the first series) and on the model of infected wound with delayed application of the glue (after 3 days) after trauma (the second series).