Germline ecology: Managed herds, tolerated flocks, and pest control

Abstract Multicopy sequences evolve adaptations for increasing their copy number within nuclei. The activities of multicopy sequences under constraints imposed by cellular and organismal selection result in a rich intranuclear ecology in germline cells. Mitochondrial and ribosomal DNA are managed as...

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Published inThe Journal of heredity Vol. 115; no. 6; pp. 643 - 659
Main Author Haig, David
Format Journal Article
LanguageEnglish
Published US Oxford University Press 23.10.2024
Subjects
DNA Transposable Elements
DNA, Mitochondrial - genetics
DNA, Ribosomal - genetics
Germ Cells
rDNA
satellite DNA
mtDNA
intragenomic conflict
centromeres
concerted evolution
oocyte atresia
transposable elements
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Summary:Abstract Multicopy sequences evolve adaptations for increasing their copy number within nuclei. The activities of multicopy sequences under constraints imposed by cellular and organismal selection result in a rich intranuclear ecology in germline cells. Mitochondrial and ribosomal DNA are managed as domestic herds subject to selective breeding by the genes of the single-copy genome. Transposable elements lead a peripatetic existence in which they must continually move to new sites to keep ahead of inactivating mutations at old sites and undergo exponential outbreaks when the production of new copies exceeds the rate of inactivation of old copies. Centromeres become populated by repeats that do little harm. Organisms with late sequestration of germ cells tend to evolve more “junk” in their genomes than organisms with early sequestration of germ cells.
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ISSN:0022-1503
1465-7333
1465-7333
DOI:10.1093/jhered/esae004