Epithelioid leiomyosarcoma of the stomach. A case study of the intermediate filaments

The intermediate filament typing of skeletal and smooth muscle tumors has shown that these neoplasms are characterized by the combined expression of desmin and vimentin intermediate filaments. A case of epithelioid leiomyosarcoma of the stomach was studied by conventional light microscopy and by ind...

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Bibliographic Details
Published inThe American journal of surgical pathology Vol. 11; no. 7; p. 575
Main Authors Suster, S, Huszar, M
Format Journal Article
LanguageEnglish
Published United States 01.07.1987
Subjects
Cytoskeleton - ultrastructure
Female
Fluorescent Antibody Technique
Humans
Intermediate Filaments - ultrastructure
Leiomyosarcoma - pathology
Leiomyosarcoma - ultrastructure
Microscopy, Electron
Middle Aged
Stomach Neoplasms - pathology
Stomach Neoplasms - ultrastructure
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Summary:The intermediate filament typing of skeletal and smooth muscle tumors has shown that these neoplasms are characterized by the combined expression of desmin and vimentin intermediate filaments. A case of epithelioid leiomyosarcoma of the stomach was studied by conventional light microscopy and by indirect immunofluorescence using tissue-specific antibodies against intermediate filaments. The tumor cells labeled strongly with vimentin antibodies and were negative for desmin and prekeratin. This peculiar staining pattern may be the result of poor differentiation of the tumor cells with resultant loss of expression of desmin, or may be due to origin from a distinctive smooth muscle cell characterized by the exclusive expression of vimentin intermediate filaments.
ISSN:0147-5185
1532-0979
DOI:10.1097/00000478-198707000-00011