Ca2+ signaling, intracellular pH and cell volume in cell proliferation

Mitogens control progression through the cell cycle in non-transformed cells by complex cascades of intracellular messengers, such as Ca2+ and protons, and by cell volume changes. Intracellular Ca2+ and proton concentrations are critical for linking external stimuli to proliferation, motility, apopt...

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Bibliographic Details
Published inThe Journal of membrane biology Vol. 205; no. 3; pp. 129 - 137
Main Author Schreiber, R
Format Journal Article
LanguageEnglish
Published United States Springer Nature B.V 01.06.2005
Subjects
Animals
Apoptosis
Calcium (intracellular)
Calcium - metabolism
Calcium channels
Calcium Channels - physiology
Calcium influx
Calcium ions
Calcium Signaling - physiology
Calcium signalling
Cell cycle
Cell Cycle - physiology
Cell growth
Cell Proliferation
Cell Size
External stimuli
Humans
Hydrogen-Ion Concentration
Intracellular
Intracellular signalling
Kinases
Membrane Potentials - physiology
Mitogens
Mitogens - pharmacology
pH effects
Protons
Sodium-Hydrogen Exchangers - physiology
Transformed cells
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Summary:Mitogens control progression through the cell cycle in non-transformed cells by complex cascades of intracellular messengers, such as Ca2+ and protons, and by cell volume changes. Intracellular Ca2+ and proton concentrations are critical for linking external stimuli to proliferation, motility, apoptosis and differentiation. This review summarizes the role in cell proliferation of calcium release from intracellular stores and the Ca2+ entry through plasma membrane Ca2+ channels. In addition, the impact of intracellular pH and cell volume on cell proliferation is discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0022-2631
1432-1424
DOI:10.1007/s00232-005-0778-z