Three-Component Synthesis of 3-Aminomethylene-thiochroman-2,4-diones from 4-Hydroxythiocoumarin

A three-component synthesis of 3-aminomethylene-thiochroman-2,4-dione derivatives 2-22 by the condensation reactions of amines, α-aminoacids, ureas, and carbamates with 4-hydroxythiocoumarin 1, respectively, in the presence of triethyl orthofomate is described.

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Bibliographic Details
Published inSynthetic communications Vol. 34; no. 11; pp. 2053 - 2061
Main Authors Park, Hyun-Ja, Lee, Kee-In
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis Group 31.12.2004
Taylor & Francis
Subjects
3-Methylene-thiochroman-2,4-dione
4-Hydroxythiocoumarin
Amine
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Three-component condensation
Triethyl orthofomate
EFFICIENT SYNTHESIS
GLYCINE SITE
RECEPTOR
three-component condensation
COUMARINS
3-methylene-thibchroman-2,4-dione
triethyl orthofornate
BETA,BETA-DIACYL-ENAMINES
4-HYDROXYCOUMARIN
4-hydroxythiocoumarin
BRODIFACOUM
DIPHENACOUM
ANTAGONISTS
amine
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Summary:A three-component synthesis of 3-aminomethylene-thiochroman-2,4-dione derivatives 2-22 by the condensation reactions of amines, α-aminoacids, ureas, and carbamates with 4-hydroxythiocoumarin 1, respectively, in the presence of triethyl orthofomate is described.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-120037919