Network-wise analysis of movie-specific information in dynamic functional connectivity using COBE

• Published in: Cerebral cortex (New York, N.Y. 1991) Vol. 34; no. 4
• Main Authors: Mittal, Priyanka, Sao, Anil K, Biswal, Bharat, Di, Xin, Dileep, Aroor Dinesh
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.04.2024
• Subjects: Adult; Brain - diagnostic imaging; Brain - physiology; Brain Mapping - methods; Female; Humans; Image Processing, Computer-Assisted - methods; Magnetic Resonance Imaging - methods; Male; Motion Pictures; Nerve Net - diagnostic imaging; Nerve Net - physiology; Neural Pathways - physiology; Photic Stimulation - methods; Young Adult; brain connectivity; COBE; fMRI; DTW; movie watching
• ISSN: 1047-3211; 1460-2199; 1460-2199
• DOI: 10.1093/cercor/bhae170

Movie watching during functional magnetic resonance imaging has emerged as a promising tool to measure the complex behavior of the brain in response to a stimulus similar to real-life situations. It has been observed that presenting a movie (sequence of events) as a stimulus will lead to a unique time course of dynamic functional connectivity related to movie stimuli that can be compared across the participants. We assume that the observed dynamic functional connectivity across subjects can be divided into following 2 components: (i) specific to a movie stimulus (depicting group-level behavior in functional connectivity) and (ii) individual-specific behavior (not necessarily common across the subjects). In this work, using the dynamic time warping distance measure, we have shown the extent of similarity between the temporal sequences of functional connectivity while the underlying movie stimuli were same and different. Further, the temporal sequence of functional connectivity patterns related to a movie is enhanced by suppressing the subject-specific components of dynamic functional connectivity using common and orthogonal basis extraction. Quantitative analysis using the F-ratio measure reveals significant differences in dynamic functional connectivity within the somatomotor network and default mode network, as well as between the occipital network and somatomotor networks.