The application of alkaloids in ferroptosis: A review

• Published in: Biomedicine & pharmacotherapy Vol. 178; p. 117232
• Main Authors: Fan, Bocheng, Guo, Qihao, Wang, Shu
• Format: Journal Article
• Language: English
• Published: Elsevier Masson SAS 01.09.2024; Elsevier
• Subjects: alkaloid; ferroptosis; GPX4-regulated ferroptosis; iron metabolism; lipid metabolism; Nrf2 pathway; PEBP1; alkaloid; 4EBP1; iron metabolism; BBR; LC3; PUFA-PL; AA; TFR; USP47; AD; GPX4; PUFA; MT; NCOA4; 3 × Tg-AD; ACSL4; ER; SIRT3; ARE; ROS; GPX4-regulated ferroptosis; ATF3; ATF4; NADPH; ABC; System Xc; ferroptosis; PGC1α; FPN; lipid metabolism; FoxO3a; ALOX; HO-1; Piezo1; TXN; Bmal1; Nrf2; UCP2; P13K/Akt; EIF4E; GSH; Fe; TXNRD1; Nrf2 pathway; TF; PE; Keap1; STUB1; MCU

Alkaloids have remarkable biological and pharmacological properties and have recently garnered extensive attention. Various alkaloids, including commercially available drugs such as berberine, substantially affect ferroptosis. In addition to the three main pathways of ferroptosis, iron metabolism, p...