The application of alkaloids in ferroptosis: A review

• Published in: Biomedicine & pharmacotherapy Vol. 178; p. 117232
• Main Authors: Fan, Bocheng, Guo, Qihao, Wang, Shu
• Format: Journal Article
• Language: English
• Published: Elsevier Masson SAS 01.09.2024; Elsevier
• Subjects: alkaloid; ferroptosis; GPX4-regulated ferroptosis; iron metabolism; lipid metabolism; Nrf2 pathway; PEBP1; alkaloid; 4EBP1; iron metabolism; BBR; LC3; PUFA-PL; AA; TFR; USP47; AD; GPX4; PUFA; MT; NCOA4; 3 × Tg-AD; ACSL4; ER; SIRT3; ARE; ROS; GPX4-regulated ferroptosis; ATF3; ATF4; NADPH; ABC; System Xc; ferroptosis; PGC1α; FPN; lipid metabolism; FoxO3a; ALOX; HO-1; Piezo1; TXN; Bmal1; Nrf2; UCP2; P13K/Akt; EIF4E; GSH; Fe; TXNRD1; Nrf2 pathway; TF; PE; Keap1; STUB1; MCU
• ISSN: 0753-3322; 1950-6007; 1950-6007
• DOI: 10.1016/j.biopha.2024.117232

Alkaloids have remarkable biological and pharmacological properties and have recently garnered extensive attention. Various alkaloids, including commercially available drugs such as berberine, substantially affect ferroptosis. In addition to the three main pathways of ferroptosis, iron metabolism, phospholipid metabolism, and the glutathione peroxidase 4-regulated pathway, novel mechanisms of ferroptosis are continuously being identified. Alkaloids can modulate the progression of various diseases through ferroptosis and exhibit the ability to exert varied effects depending on dosage and tissue type underscores their versatility. Therefore, this review comprehensively summarizes primary targets and the latest advancements of alkaloids in ferroptosis, as well as the dual roles of alkaloids in inhibiting and promoting ferroptosis.