Long-term follow-up of type II membranoproliferative glomerulonephritis in two children

• Published in: Clinical and experimental nephrology Vol. 7; no. 1; pp. 58 - 62
• Main Authors: Iitaka, Kikuo, Nakamura, Shinya, Moriya, Shunsuke, Koshino, Hiroe, Iwasaki, Naomi, Motoyama, Osamu, Sakai, Tadasu
• Format: Journal Article
• Language: English
• Published: Japan Springer Nature B.V 01.03.2003
• Subjects: Basement Membrane - pathology; Biopsy; Child; Dipyridamole - administration & dosage; Female; Follow-Up Studies; Glomerular Mesangium - pathology; Glomerulonephritis, Membranoproliferative - drug therapy; Glomerulonephritis, Membranoproliferative - pathology; Glomerulonephritis, Membranoproliferative - urine; Hematuria; Humans; Immunoglobulin M - analysis; Kidney - pathology; Kidney Glomerulus - pathology; Male; Microscopy, Electron; Prednisolone - administration & dosage; Proteinuria
• ISSN: 1342-1751; 1437-7799
• DOI: 10.1007/s101570300008

We report the long-term follow-up of two patients with type II membranoproliferative glomerulonephritis (MPGN). One Patients was treated with high-dose alternate-day prednisolone and the other with dipyridamole. Both had favorable clinical courses over 8.5 and 15.5 years of follow-up, respectively. One patient who showed diffuse proliferative changes lost the urinary abnormalities 2 years after starting treatment. Her follow-up renal biopsies showed histological improvement. In the other patient, a boy, renal biopsy performed 6 years after the onset showed mild mesangial proliferation and a moderate matrix increase. His urine became normal 14 years after onset. Intramembranous electron-dense deposits persisted in these patients over 7 and 6 years of observation, respectively. Patients with type II MPGN are usually difficult to treat and often progress to endstage renal failure. There is, however, a group of patients who have a favorable clinical course.