Synthesis of Kojic Acid Derivatives Containing Phenolic Hydroxy Groups

Two kojic acid derivatives (2a and 2b) containing phenolic hydroxy groups were synthesized. The preparation was carried out by the reaction of a kojic acid derivative (3) having a chloromethyl group with phenol derivatives (4 and 7), followed by the subsequent deprotection steps. The first reaction...

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Bibliographic Details
Published inSynthetic communications Vol. 33; no. 7; pp. 1081 - 1086
Main Authors Kadokawa, J., Nishikura, T., Muraoka, R., Tagaya, H., Fukuoka, N.
Format Journal Article
LanguageEnglish
Published NEW YORK Taylor & Francis Group 05.01.2003
Marcel Dekker Inc
Subjects
Chemistry
Chemistry, Organic
Deprotection
Kojic acid
Phenolic hydroxy group
Physical Sciences
Science & Technology
Tylosinase inhibitor
VITAMIN-C
deprotection
phenolic hydroxy group
kojic acid
tylosinase inhibitor
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Summary:Two kojic acid derivatives (2a and 2b) containing phenolic hydroxy groups were synthesized. The preparation was carried out by the reaction of a kojic acid derivative (3) having a chloromethyl group with phenol derivatives (4 and 7), followed by the subsequent deprotection steps. The first reaction proceeded smoothly in the presence of potassium carbonate in DMF at room temperature. Then, the appropriate deprotection reactions gave the desired compounds 2a and 2b. The structures of 2a and 2b were confirmed by the 1 H NMR spectra.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-120017129