Bismuth Subnitrate Catalyzed Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones: An Improved Protocol for the Biginelli Reaction
An efficient synthesis of 3,4-dihydropyrimidinones (DHPMs) using bismuth subnitrate as the catalyst for the first time from an aldehyde, β-ketoester, and urea in acetonitrile is described. This new method consistently has the advantage of excellent yields (88-96%) and short reaction times (1.5-4 h)...
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Published in | Synthetic communications Vol. 34; no. 20; pp. 3821 - 3825 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
PHILADELPHIA
Taylor & Francis Group
01.01.2004
Taylor & Francis |
Subjects | |
Online Access | Get full text |
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Summary: | An efficient synthesis of 3,4-dihydropyrimidinones (DHPMs) using bismuth subnitrate as the catalyst for the first time from an aldehyde, β-ketoester, and urea in acetonitrile is described. This new method consistently has the advantage of excellent yields (88-96%) and short reaction times (1.5-4 h) than do classical Biginelli reaction conditions. |
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ISSN: | 0039-7911 1532-2432 |
DOI: | 10.1081/SCC-200032533 |