Bismuth Subnitrate Catalyzed Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones: An Improved Protocol for the Biginelli Reaction

An efficient synthesis of 3,4-dihydropyrimidinones (DHPMs) using bismuth subnitrate as the catalyst for the first time from an aldehyde, β-ketoester, and urea in acetonitrile is described. This new method consistently has the advantage of excellent yields (88-96%) and short reaction times (1.5-4 h)...

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Bibliographic Details
Published inSynthetic communications Vol. 34; no. 20; pp. 3821 - 3825
Main Authors Thirupathi Reddy, Y., Rajitha, B., Narsimha Reddy, P., Sunil Kumar, B., Rao, V. P.
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis Group 01.01.2004
Taylor & Francis
Subjects
Biginelli reaction
Bismuth subnitrate
Chemistry
Chemistry, Organic
Dihydropyrimidinones
One-pot condensation
Physical Sciences
Science & Technology
dihydropyrimidinones
Biginelli reaction
one-pot condensation
ONE-POT SYNTHESIS
bismuth subnitrate
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Summary:An efficient synthesis of 3,4-dihydropyrimidinones (DHPMs) using bismuth subnitrate as the catalyst for the first time from an aldehyde, β-ketoester, and urea in acetonitrile is described. This new method consistently has the advantage of excellent yields (88-96%) and short reaction times (1.5-4 h) than do classical Biginelli reaction conditions.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-200032533