2′-C-ALKOXY AND 2′-C-ARYLOXY DERIVATIVES OF N-(2-PHOSPHONOMETHOXYETHYL)-PURINES AND -PYRIMIDINES: SYNTHESIS AND BIOLOGICAL ACTIVITY

A series of novel, unusual type of acyclic phosphonate-based nucleotide analogues related to well-known antivirals (PMEA and HPMPA) was synthesized using easily available synthon. These compounds, which are distinguished for the presence of phosphonomethyl acetal linkage, form a group of derivatives...

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Bibliographic Details
Published inNucleosides, nucleotides & nucleic acids Vol. 20; no. 8; pp. 1497 - 1522
Main Authors Rejman, Dominik, Masojídková, Milena, De Clercq, Eric, Rosenberg, Ivan
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis Group 31.07.2001
Taylor & Francis
Subjects
Biochemistry & Molecular Biology
Life Sciences & Biomedicine
Science & Technology
AGENT
IN-VITRO
POTENT
VIVO
BOND
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Summary:A series of novel, unusual type of acyclic phosphonate-based nucleotide analogues related to well-known antivirals (PMEA and HPMPA) was synthesized using easily available synthon. These compounds, which are distinguished for the presence of phosphonomethyl acetal linkage, form a group of derivatives that contribute to the understanding of structure-activity relationship within the area of acyclic nucleotide analogues.
ISSN:1525-7770
1532-2335
DOI:10.1081/NCN-100105244