4-{[5-(4-Chlorophenyl)-1-(4-fluorophenyl)-1 H -pyrazol-3-yl]carbonyl}- N -ethylpiperazine-1-carboxamide

• Published in: Acta crystallographica. Section E, Structure reports online Vol. 67; no. 7; pp. o1747 - o1748
• Main Authors: Shahani, Tara, Fun, Hoong-Kun, Vijayakumar, V., Ragavan, R. Venkat, Sarveswari, S.
• Format: Journal Article
• Language: English
• Published: International Union of Crystallography 01.07.2011
• ISSN: 1600-5368; 1600-5368
• DOI: 10.1107/S1600536811023178

The asymmetric unit of the title compound, C23H23ClFN5O2, contains two crystallographically independent molecules. In one molecule, the pyrazole ring makes dihedral angles of 43.93 (7) and 35.82 (7)°, respectively, with the fluoro- and chloro-substituted benzene rings, while the corresponding angles in the other molecule are 52.26 (8) and 36.85 (7)°. The piperazine rings adopt chair conformations. In the crystal, adjacent molecules are connected via intermolecular N—H...O, C—H...F, C—H...N and C—H...O hydrogen bonds, forming a two-dimensional network parallel to the bc plane. The crystal structure is further stabilized by a weak π–π interaction with a centroid–centroid distance of 3.6610 (8) Å and by C—H...π interactions.