CXCR3-Expressing T Cells in Infections and Autoimmunity

The chemokine receptor CXCR3 and its ligands (MIG/CXCL9, IP-10/CXCL10, and I-TAC/CXCL11) play a central role in the generation of cellular inflammation, both in the protective responses to invading pathogens, and in different pathological conditions associated with autoimmunity. It is worth noting t...

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Published inFrontiers in bioscience (Landmark. Print) Vol. 29; no. 8; p. 301
Main Authors Rubinstein, Artem, Kudryavtsev, Igor, Arsentieva, Natalia, Korobova, Zoia R, Isakov, Dmitry, Totolian, Areg A
Format Journal Article
LanguageEnglish
Published Singapore IMR Press 22.08.2024
Subjects
Animals
Autoimmune Diseases - immunology
Autoimmune Diseases - metabolism
autoimmunity
Autoimmunity - immunology
covid-19
cxcr3 chemokines
cxcr3 receptor
cxcr3+ treg
follicular th cell subsets
Humans
infection
Infections - immunology
Inflammation - immunology
Inflammation - metabolism
Receptors, CXCR3 - immunology
Receptors, CXCR3 - metabolism
T-Lymphocytes - immunology
T-Lymphocytes - metabolism
tc1
th1 cells
th17.1 cells
COVID-19
infection
Tc1
Th1 cells
Th17.1 cells
autoimmunity
CXCR3 chemokines
CXCR3
Treg
CXCR3 receptor
follicular Th cell subsets
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Summary:The chemokine receptor CXCR3 and its ligands (MIG/CXCL9, IP-10/CXCL10, and I-TAC/CXCL11) play a central role in the generation of cellular inflammation, both in the protective responses to invading pathogens, and in different pathological conditions associated with autoimmunity. It is worth noting that CXCR3 is highly expressed on innate and adaptive lymphocytes, as well as on various cell subsets that are localized in non-immune organs and tissues. Our review focuses exclusively on CXCR3-expressing T cells, including Th1, Th17.1, Tfh17, Tfh17.1, CXCR3 Treg cells, and Tc1 CD8 T cells. Currently, numerous studies have highlighted the role of CXCR3-dependent interactions in the coordination of inflammation in the peripheral tissues, both to increase recruitment of CD4 and CD8 T cells that upregulate inflammation, and also for recruitment of CXCR3 T regulatory cells to dampen overexuberant responses. Understanding the role of CXCR3 and its ligands might help to apply them as new and effective therapeutic targets in a wide range of diseases.
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ISSN:2768-6701
2768-6698
2768-6698
DOI:10.31083/j.fbl2908301