Establishment of enzyme immunoassay for measuring serum sultopride levels

Measurement of serum sultopride levels was performed using an enzyme immunoassay. Little or no cross-reactivity with metabolites of sultopride and other drugs was found. The results of reproducibility, recovery, and dilution testing were all good enough for clinical use. A comparison between the mea...

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Bibliographic Details
Published inTherapeutic drug monitoring Vol. 23; no. 3; p. 277
Main Authors Someya, T, Shimoda, K, Muratake, T, Nakajima, E, Shirai, A, Funaoka, H, Yashiki, T, Ishii, H, Sunahara, N, Takahashi, S
Format Journal Article
LanguageEnglish
Published United States 01.06.2001
Subjects
Adult
Aged
Amisulpride
Antipsychotic Agents - blood
Chromatography, High Pressure Liquid
Female
Humans
Immunoenzyme Techniques
Male
Middle Aged
Sulpiride - analogs & derivatives
Sulpiride - blood
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Summary:Measurement of serum sultopride levels was performed using an enzyme immunoassay. Little or no cross-reactivity with metabolites of sultopride and other drugs was found. The results of reproducibility, recovery, and dilution testing were all good enough for clinical use. A comparison between the measurement values of this method (y) with that of high-performance liquid chromatography (x) showed high correlation (n = 211, r = 0.991, p < 0.0001, y = 0.99x + 107.5). In a comparison between the sultopride dose and serum levels in 161 patients, interindividual differences were large (19 times for same doses), implying that the serum level cannot be predicted from the dosage. The method was found to be reliable for serum level measurements of sultopride and useful for monitoring compliance and assessing the optimal dose.
ISSN:0163-4356
DOI:10.1097/00007691-200106000-00016