Use of Prothrombin Complex Concentrate in Oral Anticoagulant-Associated Major Bleeding

Severe bleeding remains the most significant adverse effect associated with both warfarin and the direct oral anticoagulant agents. Due to the life-threatening nature of these bleeds, knowledge and understanding of agents that are able to rapidly overcome the anticoagulation effects of these medicat...

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Bibliographic Details
Published inCritical care nursing quarterly Vol. 45; no. 2; p. 167
Main Authors Lukas, Jack G, Reichert, Michael J, Jones, G Morgan
Format Journal Article
LanguageEnglish
Published United States 01.04.2022
Subjects
Anticoagulants - adverse effects
Blood Coagulation Factors - therapeutic use
Hemorrhage - chemically induced
Hemorrhage - drug therapy
Humans
Retrospective Studies
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Summary:Severe bleeding remains the most significant adverse effect associated with both warfarin and the direct oral anticoagulant agents. Due to the life-threatening nature of these bleeds, knowledge and understanding of agents that are able to rapidly overcome the anticoagulation effects of these medications is paramount to their use. Worldwide, the most commonly used agent for this indication is prothrombin complex concentrate (PCC). This review summarizes the evidence on the use of PCC in this population and provides practical information regarding patient-specific administration considerations.
ISSN:1550-5111
DOI:10.1097/CNQ.0000000000000399