New Synthesis of Alkyl 1-tert-Butyl-4,4-dimethyl-2,5-dioxo-pyrrolidine-3-carboxylate and Dialkyl 2-(1-tert-Butylcarbamoyl-1- methyl-ethyl)-malonates

5-Isopropylidene-2,2-dimethyl-1,3-dioxane-4,6-dione (the condensation product of Meldrum's acid and acetone) reacts smoothly with tert-butyl isocyanide in the presence of alcohols to produce alkyl 1-tert-butyl-4,4-dimethyl-2,5-dioxo-pyrrolidine-3-carboxylate and dialkyl 2-(1-tert-butylcarbamoyl...

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Bibliographic Details
Published inSynthetic communications Vol. 33; no. 15; pp. 2709 - 2717
Main Authors Yavari, Issa, Hosseini-Tabatabaei, Mohammad R., Habibi, Azizollah
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis Group 08.01.2003
Taylor & Francis
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
MELDRUMS ACID
ISOCYANIDES
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Summary:5-Isopropylidene-2,2-dimethyl-1,3-dioxane-4,6-dione (the condensation product of Meldrum's acid and acetone) reacts smoothly with tert-butyl isocyanide in the presence of alcohols to produce alkyl 1-tert-butyl-4,4-dimethyl-2,5-dioxo-pyrrolidine-3-carboxylate and dialkyl 2-(1-tert-butylcarbamoyl-l-methyl-ethyl)-malonates in good overall yields.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-120021994