An Efficient Synthesis of 5-Bromopyridine-2-carbonitrile

5-Bromopyridine-2-carbonitrile was efficiently synthesized in two steps from 2,5-dibromopyridine with an overall yield of 75%.

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Bibliographic Details
Published inSynthetic communications Vol. 33; no. 19; pp. 3285 - 3289
Main Authors Markevitch, David Y., Rapta, Miroslav, Hecker, Scott J., Renau, Thomas E.
Format Journal Article
LanguageEnglish
Published PHILADELPHIA Taylor & Francis Group 01.09.2003
Taylor & Francis
Subjects
Acid catalyzed amide dehydration
Chemistry
Chemistry, Organic
Nucleophilic aromatic substitution
Pd-catalyzed cross coupling
Physical Sciences
Science & Technology
CYANATION
ACID
nucleophilic aromatic substitution
acid catalyzed amide dehydration
Pd-catalyzed cross coupling
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Summary:5-Bromopyridine-2-carbonitrile was efficiently synthesized in two steps from 2,5-dibromopyridine with an overall yield of 75%.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-120023985