Looking but Not Seeing: Recent Perspectives on Posterior Cortical Atrophy

• Published in: Current directions in psychological science : a journal of the American Psychological Society Vol. 25; no. 4; pp. 251 - 260
• Main Authors: Crutch, Sebastian J., Yong, Keir X. X., Shakespeare, Timothy J.
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.08.2016; SAGE PUBLICATIONS, INC
• Subjects: Brain; Dementia; Dyslexia; Memory; Visual aids; posterior cortical atrophy; vision; Alzheimer’s disease; crowding; oculomotor; dyslexia
• ISSN: 0963-7214; 1467-8721
• DOI: 10.1177/0963721416655999

Posterior cortical atrophy (PCA) is the canonical "visual dementia," with affected individuals experiencing a progressive disintegration of their visual world owing to dysfunction and atrophy at the back of the brain. The syndrome, which also affects literacy, numeracy, and gesture, is typically caused by Alzheimer's disease, but is distinguished from more common amnestic presentations by virtue of relatively preserved episodic memory and insight. Although problems with object and space perception are the most widely reported and investigated symptoms, these higher-order perceptual difficulties are often underpinned by an array of changes in more basic visual and oculomotor processes. Here we review recent studies providing insights into these more elementary aspects of vision in PCA, including fixation stability, saccade generation, point localization, excessive crowding, and factors affecting the effective field of vision. We argue that a more detailed appreciation of these fundamental changes in the early visual system not only will improve the characterization and understanding of this rare clinico-radiological syndrome but will also guide the design of visual aids and strategies aimed at maintaining everyday abilities in individuals with PCA.