Synthesis of 7-Alkoxy/Hydroxy-α-methyltryptamines
A simple method for the preparation of 7-alkoxy/hydroxy-α-methyl-DL-tryptamines is reported. The key steps of the synthesis are the Japp-Klingemann coupling of 2-piperidone-3-carboxylic acid 3 with diazonium salts 4, the Fischer-type cyclization of hydrazones 5 to β-carboline derivatives 6 and their...
Saved in:
Published in | Synthetic communications Vol. 34; no. 10; pp. 1791 - 1799 |
---|---|
Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
PHILADELPHIA
Taylor & Francis Group
31.12.2004
Taylor & Francis |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | A simple method for the preparation of 7-alkoxy/hydroxy-α-methyl-DL-tryptamines is reported. The key steps of the synthesis are the Japp-Klingemann coupling of 2-piperidone-3-carboxylic acid 3 with diazonium salts 4, the Fischer-type cyclization of hydrazones 5 to β-carboline derivatives 6 and their hydrolysis to title compounds 8. |
---|---|
ISSN: | 0039-7911 1532-2432 |
DOI: | 10.1081/SCC-120034160 |