Treatment of advanced ovarian cancer with cis-dichlorodiammine platinum in combination with cyclophosphamide. An E.C.O.G. pilot study

Twenty patients with Stage III and IV carcinoma of the ovary have been treated with a combination of cyclophosphamide and cis-platinum given every 3 weeks. Regarding toxicity, this combination probably included a too-high dose of CTX (1.1 g/m2 every 3 weeks). The response rate was 75% (15/20) but wi...

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Bibliographic Details
Published inAmerican journal of clinical oncology Vol. 6; no. 1; p. 85
Main Authors Israel, L, Aguilera, J, Breau, J L
Format Journal Article
LanguageEnglish
Published United States 01.02.1983
Subjects
Aged
Cisplatin - administration & dosage
Cisplatin - toxicity
Cyclophosphamide - administration & dosage
Cyclophosphamide - toxicity
Doxorubicin - administration & dosage
Drug Therapy, Combination
Female
Humans
Middle Aged
Ovarian Neoplasms - drug therapy
Ovarian Neoplasms - mortality
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Summary:Twenty patients with Stage III and IV carcinoma of the ovary have been treated with a combination of cyclophosphamide and cis-platinum given every 3 weeks. Regarding toxicity, this combination probably included a too-high dose of CTX (1.1 g/m2 every 3 weeks). The response rate was 75% (15/20) but with a significant duration only for those patients who achieved a complete response (7/20). It was seen that, as usual, patients who have undergone extensive reductive surgery are more likely to respond. The regimen described gives results comparable to those of more aggressive combinations but did not achieve significant control of the disease.
ISSN:0277-3732
DOI:10.1097/00000421-198302000-00014