SYNTHESIS OF NATURAL AMIDE ALKALOID PIPERDARDINE AND A NEW BIOACTIVE ANALOGUE

Piperdardine, (E,E)-1-[7-(1,3-benzodioxol-5-yl)-1-oxo-2,4-heptadienyl]-piperidine, isolated from the stem of Piper tuberculatum, was synthesized in 21% overall yield by an efficient pathway, in which safrole, an abundant Brazilian essential oil from Ocotea pretiosa, was used as starting material.

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Bibliographic Details
Published inSynthetic communications Vol. 31; no. 1; pp. 117 - 123
Main Authors de Araújo-Júnior, João X., de M. Duarte, Carolina, de O. Chaves, Maria C., Parente, José P., Fraga, Carlos A. M., Barreiro, Eliezer J.
Format Journal Article
LanguageEnglish
Published NEW YORK Taylor & Francis Group 01.01.2001
Marcel Dekker Inc
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
PIPER-SARMENTOSUM
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Summary:Piperdardine, (E,E)-1-[7-(1,3-benzodioxol-5-yl)-1-oxo-2,4-heptadienyl]-piperidine, isolated from the stem of Piper tuberculatum, was synthesized in 21% overall yield by an efficient pathway, in which safrole, an abundant Brazilian essential oil from Ocotea pretiosa, was used as starting material.
ISSN:0039-7911
1532-2432
DOI:10.1081/SCC-100000187