Composite interval mapping and multiple interval mapping: procedures and guidelines for using Windows QTL Cartographer

Tremendous progress has been made in recent years on developing statistical methods for mapping quantitative trait loci (QTL) from crosses of inbred lines. In this chapter, we provide an introduction of composite interval mapping and multiple interval mapping methods for mapping QTL from inbred line...

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Bibliographic Details
Published inMethods in molecular biology (Clifton, N.J.) Vol. 871; p. 75
Main Authors Silva, Luciano Da Costa E, Wang, Shengchu, Zeng, Zhao-Bang
Format Journal Article
LanguageEnglish
Published United States 2012
Subjects
Animals
Drosophila melanogaster - genetics
Inbreeding
Models, Statistical
Quantitative Trait Loci - genetics
Software
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Summary:Tremendous progress has been made in recent years on developing statistical methods for mapping quantitative trait loci (QTL) from crosses of inbred lines. In this chapter, we provide an introduction of composite interval mapping and multiple interval mapping methods for mapping QTL from inbred line crosses and also detailed instructions to perform the analyses in Windows QTL Cartographer. For each method, we discuss the meaning of each option in the analysis procedures and how to understand and interpret the mapping results through a work-out example.
ISSN:1940-6029
DOI:10.1007/978-1-61779-785-9_6