Twenty‐four‐hour intragastric acidity and plasma gastrin concentration in healthy subjects and patients with duodenal or gastric ulcer, or pernicious anaemia

• Published in: Alimentary pharmacology & therapeutics Vol. 1; no. 3; pp. 225 - 237
• Main Authors: LANZON‐MILLER, S., POUNDER, R. E., HAMILTON, M. R., CHRONOS, N. A. F., BALL, S., MERCIECA, J. E., OLAUSSON, M., CEDERBERG, C.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.1987
• Subjects: Adult; Aged; Anemia, Pernicious - blood; Anemia, Pernicious - physiopathology; Circadian Rhythm; Duodenal Ulcer - blood; Duodenal Ulcer - physiopathology; Female; Gastric Acid - metabolism; Gastric Acidity Determination; Gastrins - blood; Humans; Male; Middle Aged; Stomach Ulcer - blood; Stomach Ulcer - physiopathology
• ISSN: 0269-2813; 1365-2036
• DOI: 10.1111/j.1365-2036.1987.tb00622.x

SUMMARY Twenty‐four‐hour intragastric acidity and plasma gastrin concentration were measured in healthy subjects (n= 16), and patients with duodenal (n= 12) or gastric (n= 10) ulceration, or pernicious anaemia (n= 8). Median integrated 24‐hour intragastric acidity was highest in duodenal ulcer patients and lowest in pernicious anaemia patients (1148 and 0 mmol. hour litre−1, respectively). Median integrated 24‐hour plasma gastrin was highest in pernicious anaemia and lowest in the healthy subjects (9886 and 238 pmol. hour litre−1, respectively). Pernicious anaemia patients have unremitting hypergastrinaemia throughout the 24 hours. The results of this study not only provide a reference range of acidity and plasma gastrin in health and disease, but also will act as a baseline for future studies using antisecretory drugs.