Modified handling of internal catecholamine standards in radioenzymic assays

A departure from a radioenzymic procedure widely used for plasma catecholamine assay is reported, in which we use "mean net standards" instead of individual internal standards. Interlaboratory/intermethod analyses validated use of the modified principle and demonstrated its preferential us...

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Published inClinical chemistry (Baltimore, Md.) Vol. 29; no. 1; pp. 144 - 147
Main Authors Ellis, JP, Jr, Burns, JW
Format Journal Article
LanguageEnglish
Published England Am Assoc Clin Chem 01.01.1983
Subjects
Animals
Catecholamines - blood
Humans
Mathematics
Methods
Physical Exertion
Reagent Kits, Diagnostic
Reference Standards
Swine
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Summary:A departure from a radioenzymic procedure widely used for plasma catecholamine assay is reported, in which we use "mean net standards" instead of individual internal standards. Interlaboratory/intermethod analyses validated use of the modified principle and demonstrated its preferential use over the conventional principle. Also demonstrated is use of the modified procedure for calculating catecholamine concentrations of several plasma samples collected from an exercising man and an acceleration-stressed swine. Benefits already derived from use of the procedure include: (a) quantification of certain plasma samples that could not be satisfactorily quantified by conventional options, (b) an apparent gain in analytical precision in virtually all other analyses, and (c) costs of analysis reduced by about 25%.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0009-9147
1530-8561
DOI:10.1093/clinchem/29.1.144