Smart membranes for biomedical applications

• Published in: Chinese journal of chemical engineering Vol. 49; no. 9; pp. 34 - 45
• Main Authors: Zou, Lin-Bing, Gong, Jue-Ying, Ju, Xiao-Jie, Liu, Zhuang, Wang, Wei, Xie, Rui, Chu, Liang-Yin
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.09.2022; School of Chemical Engineering,Sichuan University,Chengdu 610065,China%School of Chemical Engineering,Sichuan University,Chengdu 610065,China; State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,China
• Subjects: Bioseparation; Cell culture; Controlled release; Membranes; Polymers; Smart materials; Cell culture; Membranes; Polymers; Smart materials; Controlled release; Bioseparation
• ISSN: 1004-9541; 2210-321X
• DOI: 10.1016/j.cjche.2022.06.006

[Display omitted] Smart membranes with tunable permeability and selectivity have drawn widespread attention because of their unique biomimetic characteristics. Constructed by incorporating various stimuli-responsive materials into membrane substrates, smart membranes could self-adjust their physical/chemical properties (such as pore size and surface properties) in response to environmental signals such as temperature, pH, light, magnetic field, electric field, redox and specific ions/molecules. Such smart membranes show great prospects in biomedical applications ranging from controlled drug release to bioseparation and tissue engineering. In this review, three controlled release models realized by different designed smart membranes are emphatically introduced, and then smart membranes for biological separation and controlled cell culture are introduced and discussed respectively. At last, the existing challenges of smart membranes for biomedical applications are briefly summarized, and future research topics are suggested.