Multi-Atlas MRI-Based Striatum Segmentation for 123I-FP-CIT SPECT (DAT-SPECT) Compared With the Bolt Method and SPECT-Atlas-Based Segmentation Method Toward the Accurate Diagnosis of Parkinson's Disease/Syndrome

• Published in: Frontiers in medicine Vol. 8; p. 662233
• Main Authors: Sohara, Koji, Sekine, Tetsuro, Tateno, Amane, Mizumura, Sunao, Suda, Masaya, Sakayori, Takeshi, Okubo, Yoshiro, Kumita, Shin-ichiro
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 25.05.2021
• Subjects: 123I-FP-CIT; 18F-FE-PE2I; Bolt method; Medicine; multi-atlas MRI based parcellation; positron emission tomography; semi-quantification
• ISSN: 2296-858X; 2296-858X
• DOI: 10.3389/fmed.2021.662233

Aims: This study aimed to analyze the performance of multi-atlas MRI-based parcellation for 123 I-FP-CIT SPECT (DAT-SPECT) in healthy volunteers. The proposed method was compared with the SPECT-atlas-based and Bolt methods. 18 F-FE-PE2I-PET (DAT-PET) was used as a reference. Methods: Thirty healthy subjects underwent DAT-SPECT, DAT-PET, and 3D-T1WI-MRI. We calculated the striatum uptake ratio (SUR/SBR), caudate uptake ratio (CUR), and putamen uptake ratio (PUR) for DAT-SPECT using the multi-atlas MRI-based method, SPECT-atlas-based method, and Bolt method. In the multi-atlas MRI-based method, the cerebellum, occipital cortex, and whole-brain were used as reference regions. The correlation of age with DAT-SPECT activity and the correlations of SUR/SBR, CUR, and PUR between DAT-SPECT and DAT-PET were calculated by each of the three methods. Results: The correlation between age and SUR/SBR for DAT-SPECT based on the multi-atlas MRI-based method was comparable to that based on the SPECT-atlas-based method ( r = −0.441 to −0.496 vs. −0.488). The highest correlation between DAT-SPECT and DAT-PET was observed using the multi-atlas MRI-based method with the occipital lobe defined as the reference region compared with the SPECT-atlas-based and Bolt methods (SUR, CUR, and PUR: 0.687, 0.723, and 0.676 vs. 0.698, 0.660, and 0.616 vs. 0.655). Conclusion: Multi-atlas MRI-based parcellation with the occipital lobe defined as the reference region was at least comparable to the clinical methods.