The use of molecular genetic methods for prognosis of aerobic and anaerobic performance in athletes

• Published in: Human physiology Vol. 34; no. 3; pp. 338 - 342
• Main Authors: Ahmetov, I. I., Popov, D. V., Astratenkova, I. V., Druzhevskaya, A. M., Missina, S. S., Vinogradova, O. L., Rogozkin, V. A.
• Format: Journal Article
• Language: English
• Published: Dordrecht SP MAIK Nauka/Interperiodica 01.05.2008
• Subjects: Biomedical and Life Sciences; Biomedicine; Human Physiology; Life Sciences; Rowing Ergometer; UCP3 Gene; Aerobic Performance; Anaerobic Performance; Molecular Genetic Method
• ISSN: 0362-1197; 1608-3164
• DOI: 10.1134/S0362119708030110

The distribution of genotypes and alleles of ACE (I/D polymorphism), ACTN 3 (R577X), NOS 3 (5/4), UCP 2 ( Ala 55 Val ), and UCP 3 (-55 C/T ) genes, as well as the correlation between the genotype and physiological parameters, was studied in rowers ( n = 230) and in a control group ( n = 855). The genotypes were determined by analyzing restriction fragment length polymorphism. Physiological parameters were determined with a PM 3 rowing ergometer and a MetaMax 3B gas analyzer. The frequency of the ACE II genotype was significantly higher in elite rowers ( n = 107) than in the control subjects. The frequency of the ACTN 3 XX genotype, unfavorable for development of speed and strength qualities, was twofold lower in all rowers than in the control subjects. The frequencies of the ACE I, ACTN 3 R, UCP 2 Val , and UCP 3 T alleles increased in the athletes along with an increase in skill, which suggested natural sports selection. In addition, ACE I, NOS 3 5 , UCP 2 Val , and UCP 3 T alleles correlated with a high aerobic performance. Thus, the ACE I, NOS 3 5, UCP 2 Val , and UCP 3 T alleles may be regarded as genetic markers associated with enhanced aerobic performance and may be included in a diagnostic system for prognosis of human physical performance.