The emerging role of NR2F1-AS1 in the tumorigenesis and progression of human cancer

• Published in: Pathology, research and practice Vol. 235; p. 153938
• Main Authors: Luo, Dong, Liu, Yunfei, Yuan, Shuai, Bi, Xianyun, Yang, Yongchao, Zhu, Hongwei, Li, Zhiqiang, Ji, LianDong, Yu, Xiao
• Format: Journal Article
• Language: English
• Published: Germany Elsevier GmbH 01.07.2022
• Subjects: Bone Neoplasms - genetics; Cancer; Carcinogenesis - genetics; Cell Line, Tumor; Cell Proliferation - genetics; Cell Transformation, Neoplastic - genetics; COUP Transcription Factor I - genetics; COUP Transcription Factor I - metabolism; Esophageal Neoplasms - genetics; Esophageal Squamous Cell Carcinoma - pathology; Gene Expression Regulation, Neoplastic - genetics; Humans; Liver Neoplasms - genetics; LncRNA NR2F1-AS1; MicroRNAs - genetics; Molecular mechanisms; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; lncRNAs; FOXA1; BC; ceRNA; PR; CA19-9; CSCC; AUC; DFS; LncRNA NR2F1-AS1; O-S; Molecular mechanisms; GC; IGF-1R; EC; NSCLC; OS; NR2F1-AS1; ROC; HCC; IGF-1; EMT; ER; ESCC; TC; PDAC; NB; CRC; BIRC5; MVD; HUVECs; TCM; ERK; Cancer
• ISSN: 0344-0338; 1618-0631
• DOI: 10.1016/j.prp.2022.153938

Long noncoding RNAs (lncRNAs) are transcripts of more than 200 nucleotides that lack the ability to encode protein. Convincing studies have indicated that lncRNAs can act as oncogenes or tumor suppressors by regulating gene expression. The novel lncRNA NR2F1-AS1 was recently found to be abnormally expressed in various malignancies, including hepatocellular carcinoma, gastric cancer, colorectal cancer, pancreatic cancer, breast cancer, lung cancer, thyroid cancer, esophageal squamous cell carcinoma, osteosarcoma, and neuroblastoma. NR2F1-AS1 can modify cell proliferation, invasion, migration, apoptosis, the cell cycle, and glycolysis through various mechanisms involving direct or indirect effects on pathways. Furthermore, NR2F1-AS1 may be a potential therapeutic target and prognostic marker in cancer, as it has been related to the clinicopathological characteristics of cancer patients. Here, we summarize and clarify recent research advances regarding the expression, function, molecular mechanisms, and clinical implications of NR2F1-AS1 in multiple malignant tumors. •NR2F1-AS1 is upregulated in most tumors, but decreased in CRC and CSCC.•NR2F1-AS1 functions as oncogene in the majority of malignancies, while acts as suppressor gene in a few tumors, such as CRC and CSCC.•NR2F1-AS1 can modify cell proliferation, invasion, migration, apoptosis, cell cycle mainly by CeRNA mechanism in tumors.•NR2F1-AS1 is maybe a potential prognostic and therapeutic target in cancer.