Quality of life in individuals with attenuated psychotic symptoms: Possible role of anxiety, depressive symptoms, and socio-cognitive impairments

• Published in: Psychiatry research Vol. 257; pp. 431 - 437
• Main Authors: Takahashi, Tsutomu, Higuchi, Yuko, Komori, Yuko, Nishiyama, Shimako, Nakamura, Mihoko, Sasabayashi, Daiki, Nishikawa, Yumiko, Sumiyoshi, Tomiki, Suzuki, Michio
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier B.V 01.11.2017
• Subjects: Adolescent; Adult; Anxiety - complications; Anxiety - psychology; Cognition; Cognitive Dysfunction - complications; Cognitive Dysfunction - psychology; Depression; Depression - complications; Depression - psychology; Female; Humans; Male; Negative symptoms; Psychiatric Status Rating Scales; Psychosis; Psychotic Disorders - complications; Psychotic Disorders - psychology; Quality of Life - psychology; Schizophrenia; Young Adult; CHR-P; APS; BLIPS; Schizophrenia; ARMS; Depression; SOFAS; Cognition; STAI; Psychosis; BACS; SCoRS; CAARMS; Negative symptoms; GRD; BDI-II; QLS; JART; SIPS
• ISSN: 0165-1781; 1872-7123
• DOI: 10.1016/j.psychres.2017.08.024

Individuals with Clinical High-Risk state for Psychosis (CHR-P) are reported to exhibit impaired quality of life (QOL) similar to that observed in schizophrenia, but its determinants remain unclear. We investigated the QOL of 33 subjects with CHR-P, 45 patients with schizophrenia, and 63 healthy subjects using the Quality of Life Scale (QLS). The CHR-P and schizophrenia groups were administered the Brief Assessment of Cognition in Schizophrenia (BACS), the Schizophrenia Cognition Rating Scale (SCoRS), and the Social and Occupational Functioning Assessment Scale (SOFAS) for socio-cognitive functions; and the Positive and Negative Syndrome Scale (PANSS) and the State-Trait Anxiety Inventory for clinical symptoms. The CHR-P group was also assessed using the Beck Depression Inventory. The CHR-P and schizophrenia groups had a significantly lower QLS score to the same degree compared with controls, which was predominantly associated with the SOFAS, SCoRS, and PANSS negative/general scores. For the CHR-P, the severity of anxiety and depressive symptoms was also correlated with a lower QLS score. Regression analyses demonstrated that the QLS score was predicted by SOFAS (for both groups) and SCoRS (for CHR-P) scores. Our findings suggest the importance of addressing socio-cognitive dysfunctions as well as anxiety and depressive symptoms for better QOL in CHR-P. •We examined QOL in high-risk for psychosis and schizophrenia groups.•Both groups exhibited impaired QOL to the same degree compared to controls.•Socio-cognitive deficits and negative symptoms were general determinants of QOL.•Anxiety/depressive symptoms were related to poor QOL in the high-risk group.