Metabolite structure analysis by high-resolution MS: supporting drug-development studies

Effective characterization of drug metabolites in complex biological matrices is facilitated by mass spectrometers with high resolving power, mass accuracy and sensitivity. This review begins with an overview of high-resolution MS terminology and the different types of instrumentation that are curre...

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Bibliographic Details
Published inBioanalysis Vol. 5; no. 4; pp. 463 - 479
Main Authors Wagner, David S, Pirhalla, Jill L, Bowers, Gary D
Format Journal Article
LanguageEnglish
Published England 01.02.2013
Subjects
Animals
Humans
Mass Spectrometry - instrumentation
Mass Spectrometry - methods
Pharmaceutical Preparations - chemistry
Pharmaceutical Preparations - metabolism
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Summary:Effective characterization of drug metabolites in complex biological matrices is facilitated by mass spectrometers with high resolving power, mass accuracy and sensitivity. This review begins with an overview of high-resolution MS terminology and the different types of instrumentation that are currently available. Metabolite structure analysis offers unique challenges and, therefore, the different types of approaches used to solve problems are highlighted through specific examples. Overall, this review describes the value that high-resolution MS brings to drug-metabolism studies.
ISSN:1757-6180
1757-6199
DOI:10.4155/bio.13.3