Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies
Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life. Unfortunately, clinical outcomes for osteosarcoma patients have not substantially improved in over 30 years. This stagnation in therapeutic advances is perhaps explained by the gen...
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| Published in | Critical reviews in oncogenesis Vol. 20; no. 3-4; p. 173 |
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| Main Authors | , |
| Format | Journal Article |
| Language | English |
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United States
01.01.2015
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| Abstract | Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life. Unfortunately, clinical outcomes for osteosarcoma patients have not substantially improved in over 30 years. This stagnation in therapeutic advances is perhaps explained by the genetic, epigenetic, and biological complexities of this rare tumor. In this review we provide a general background on the biology of osteosarcoma and the clinical status quo. We go on to enumerate the genetic and epigenetic defects identified in osteosarcoma. Finally, we discuss ongoing large-scale studies in the field and potential new therapies that are currently under investigation. |
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| AbstractList | Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life. Unfortunately, clinical outcomes for osteosarcoma patients have not substantially improved in over 30 years. This stagnation in therapeutic advances is perhaps explained by the genetic, epigenetic, and biological complexities of this rare tumor. In this review we provide a general background on the biology of osteosarcoma and the clinical status quo. We go on to enumerate the genetic and epigenetic defects identified in osteosarcoma. Finally, we discuss ongoing large-scale studies in the field and potential new therapies that are currently under investigation. |
| Author | Khanna, Chand Morrow, James J |
| Author_xml | – sequence: 1 givenname: James J surname: Morrow fullname: Morrow, James J organization: Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio – sequence: 2 givenname: Chand surname: Khanna fullname: Khanna, Chand organization: Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26349415$$D View this record in MEDLINE/PubMed |
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| Snippet | Osteosarcoma is the most common primary malignancy of bone, typically presenting in the first or second decade of life. Unfortunately, clinical outcomes for... |
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| SubjectTerms | Animals Bone Neoplasms - diagnosis Bone Neoplasms - genetics Bone Neoplasms - therapy Epigenesis, Genetic - genetics Genetic Association Studies - methods Genetic Association Studies - trends Humans MicroRNAs - genetics Osteosarcoma - diagnosis Osteosarcoma - genetics Osteosarcoma - therapy |
| Title | Osteosarcoma Genetics and Epigenetics: Emerging Biology and Candidate Therapies |
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