Small RNA-mediated genome rearrangement pathways in ciliates

Most eukaryotes employ a combination of transcriptional and post-transcriptional silencing mechanisms to suppress transposons, yet ciliates employ a more extreme approach. They separate germline and somatic functions into distinct nuclei, enabling the elimination of transposons from the active somat...

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Bibliographic Details
Published inTrends in genetics Vol. 39; no. 2; pp. 94 - 97
Main Authors Gao, Yunyi, Solberg, Therese, Wang, Chundi, Gao, Feng
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2023
Subjects
Cell Nucleus - genetics
ciliate
Ciliophora - genetics
DNA elimination
Gene Rearrangement - genetics
Genome - genetics
genome rearrangement
nuclear dimorphism
RNA
small RNA
transposons
DNA elimination
transposons
small RNA
genome rearrangement
nuclear dimorphism
ciliate
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Summary:Most eukaryotes employ a combination of transcriptional and post-transcriptional silencing mechanisms to suppress transposons, yet ciliates employ a more extreme approach. They separate germline and somatic functions into distinct nuclei, enabling the elimination of transposons from the active somatic genome through diverse small RNA-mediated genome rearrangement pathways during sexual processes.
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ISSN:0168-9525
DOI:10.1016/j.tig.2022.10.001