Clarithromycin-induced acute liver injury in a patient with positive Helicobacter pylori: a case report and review of the literature

• Published in: Annals of medicine and surgery Vol. 85; no. 9; pp. 4629 - 4632
• Main Authors: Sharma, Nava Raj, Wagle, Abhishesh, Bist, Manoj, Panthi, Bishal, Pokhrel Dahal, Ritu, Rokaya, Rajesh, Shrestha, Rayana, Pokhrel, Madalasa
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 01.09.2023
• Subjects: Case Reports
• ISSN: 2049-0801; 2049-0801
• DOI: 10.1097/MS9.0000000000001135

Introduction and importance: While 14-day triple therapy with clarithromycin is a common approach for eradicating Helicobacter pylori infection, it is essential to note that this treatment does not come without potential side effects. Case presentation: We present the case of a 34-year-old male who presented to the emergency department with severe vomiting and abdominal pain. Subsequent evaluation revealed that the patient had developed drug-induced liver injury (DILI). Clinical discussion: DILI can cause acute hepatocellular or cholestatic damage, and chronic injury can lead to hepatocellular, cholestatic, vascular, or neoplastic manifestations. Conclusion: Clinicians should exercise caution and be alert to the potential hepatotoxic effects of medications, especially when initiating triple therapy for H. pylori infection.