Allyl Dibenzoylmethane Derivative: Antimelanoma Activity and Study of Its Molecular Mechanism of Interaction with DNA

• Published in: Journal of the Brazilian Chemical Society Vol. 32; no. 7; pp. 1491 - 1497
• Main Authors: Baeta, Jefferson, Andrade, Ulisses, Oliveira, Rayane, Oliveira, Leandro, Santos, Anésia, Diaz-Muñoz, Gaspar, Rocha, Márcio, Diaz, Marisa
• Format: Journal Article
• Language: English
• Published: Sociedade Brasileira de Química 01.07.2021
• Subjects: CHEMISTRY, MULTIDISCIPLINARY; Tm5 cells; optical tweezers; DPAP; DNA; B16F10 cells; dacarbazine

In this study, we assessed the cytotoxic effect of 1,3-diphenyl-2-allyl-1,3-propanedione (DPAP) on B16F10 and Tm5 melanoma cells and investigated its interaction with DNA (deoxyribonucleic acid) using optical tweezers. The compound showed to be effective against B16F10 cells with selectivity index (...