Allyl Dibenzoylmethane Derivative: Antimelanoma Activity and Study of Its Molecular Mechanism of Interaction with DNA

In this study, we assessed the cytotoxic effect of 1,3-diphenyl-2-allyl-1,3-propanedione (DPAP) on B16F10 and Tm5 melanoma cells and investigated its interaction with DNA (deoxyribonucleic acid) using optical tweezers. The compound showed to be effective against B16F10 cells with selectivity index (...

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Published inJournal of the Brazilian Chemical Society Vol. 32; no. 7; pp. 1491 - 1497
Main Authors Baeta, Jefferson, Andrade, Ulisses, Oliveira, Rayane, Oliveira, Leandro, Santos, Anésia, Diaz-Muñoz, Gaspar, Rocha, Márcio, Diaz, Marisa
Format Journal Article
LanguageEnglish
Published Sociedade Brasileira de Química 01.07.2021
Subjects
CHEMISTRY, MULTIDISCIPLINARY
Tm5 cells
optical tweezers
DPAP
DNA
B16F10 cells
dacarbazine
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Abstract In this study, we assessed the cytotoxic effect of 1,3-diphenyl-2-allyl-1,3-propanedione (DPAP) on B16F10 and Tm5 melanoma cells and investigated its interaction with DNA (deoxyribonucleic acid) using optical tweezers. The compound showed to be effective against B16F10 cells with selectivity index (SI) of 7.92 and interaction to the outer surface of the double helix, probably at the minor groove of DNA. This likely induced a bending deformation of the polymer chain, decreasing persistence length, and indicated that each DPAP molecule occupies a single base pair upon binding to the double helix.
AbstractList In this study, we assessed the cytotoxic effect of 1,3-diphenyl-2-allyl-1,3-propanedione (DPAP) on B16F10 and Tm5 melanoma cells and investigated its interaction with DNA (deoxyribonucleic acid) using optical tweezers. The compound showed to be effective against B16F10 cells with selectivity index (SI) of 7.92 and interaction to the outer surface of the double helix, probably at the minor groove of DNA. This likely induced a bending deformation of the polymer chain, decreasing persistence length, and indicated that each DPAP molecule occupies a single base pair upon binding to the double helix.
Author Oliveira, Rayane
Diaz, Marisa
Santos, Anésia
Rocha, Márcio
Oliveira, Leandro
Diaz-Muñoz, Gaspar
Andrade, Ulisses
Baeta, Jefferson
AuthorAffiliation Universidade Federal de Viçosa
Centro Federal de Educação Tecnológica de Minas Gerais
Universidade Federal de Minas Gerais
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Issue 7
Keywords Tm5 cells
optical tweezers
DPAP
DNA
B16F10 cells
dacarbazine
Language English
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Title Allyl Dibenzoylmethane Derivative: Antimelanoma Activity and Study of Its Molecular Mechanism of Interaction with DNA
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