Well-differentiated and anaplastic astroblastoma in the same patient: a case report and review of the literature

• Published in: Clinical neuropathology Vol. 34; no. 6; p. 350
• Main Authors: Samkari, Alaa, Hmoud, Mohammed, Al-Mehdar, Abeer, Abdullah, Shaker
• Format: Journal Article
• Language: English
• Published: Germany 01.11.2015
• Subjects: Adolescent; Biomarkers, Tumor - analysis; Brain Neoplasms - diagnosis; Brain Neoplasms - pathology; Brain Neoplasms - therapy; Female; Glioma - diagnosis; Glioma - pathology; Humans; Magnetic Resonance Imaging - methods; Neoplasms, Neuroepithelial - diagnosis; Neoplasms, Neuroepithelial - pathology; Neoplasms, Neuroepithelial - therapy; Treatment Outcome
• ISSN: 0722-5091
• DOI: 10.5414/NP300864

Astroblastoma is a rare brain tumor occurring in children and adults, rarely in the elderly. It constitutes up to 3% of all brain tumors. We report a case of a 14-year-old girl who presented with recurrent seizures and minimal right hemiparesis. Magnetic resonance imaging (MRI) revealed a left fronto-parietal brain tumor. It was managed with subtotal resection in a local hospital. Subsequently, she was referred to Princess Nora Oncology Center for further characterization and management. Pathology slide revision revealed well-differentiated astroblastoma. Upon follow up, the patient had multiple recurrences of the same tumor and emergence of a new lesion at the area of Sylvian fissure. Excision of the emerging tumor revealed anaplastic astroblastoma. Astroblastoma is a glial tumor that predominantly affects females. Its clinical progression is unpredictable, with high recurrence rate. Surgical intervention is considered the mainstay of treatment, while radiotherapy and chemotherapy effectiveness is debatable. To our knowledge, this is the first reported case of well-differentiated and anaplastic astroblastoma as two separate neoplastic lesions in the same patient with its clinical, radiological, and pathological features.