The Effect of Antioxidant Agents on Cisplatin-Induced Laryngeal Histological Alterations in Rats

The larynx-related adverse effects that depend on cisplatin decrease patient comfort and many antioxidants have been used to eliminate these side effects. We aimed to identify the laryngeal mucosal changes imposed by cisplatin and investigated whether antioxidants, and their healing effects on these...

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Bibliographic Details
Published inJournal of medicinal food Vol. 24; no. 2; p. 197
Main Authors Başak, Kayhan, Demir, Mehmet Gökhan, Altıntoprak, Niyazi, Aydın, Sedat
Format Journal Article
LanguageEnglish
Published United States 01.02.2021
Subjects
Animals
Antioxidants - pharmacology
Antioxidants - therapeutic use
Cisplatin
Laryngeal Diseases - chemically induced
Laryngeal Diseases - drug therapy
Larynx - drug effects
Oxidative Stress - drug effects
Rats
Rats, Wistar
larynx
mucositis
histological alterations
cisplatin
antioxidants
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Summary:The larynx-related adverse effects that depend on cisplatin decrease patient comfort and many antioxidants have been used to eliminate these side effects. We aimed to identify the laryngeal mucosal changes imposed by cisplatin and investigated whether antioxidants, and their healing effects on these changes, may help reduce laryngeal complications in patients resulting from adverse effects in the larynx. A rat model was designed to evaluate the effects of cisplatin on the larynx and the protective role of antioxidants. Single-dose cisplatin was given both intraperitoneally alone and additionally administered with p-coumaric acid, melatonin, resveratrol, vitamin D, and oleic acid over 5 days. Whole larynges were dissected and evaluated histologically, histochemically, and immunohistochemically. Varying degrees of mucosal changes cisplatin group, but neither erosion nor an ulcer was observed. Numerous variable histological effects of antioxidants were observed on cisplatin exposed laryngeal mucosa. The most obvious effects of cisplatin were edema. The results of the study showed that resveratrol was the most preventive antioxidant agent against cisplatin-dependent mucosal changes. The highest increase in the Ki67 index was in the oleic acid group. Vitamin D increased stromal cyclooxygenase-2 expression that may have an effect on increasing mucosal damage.
ISSN:1557-7600
DOI:10.1089/jmf.2019.0235