Once-Daily 0.1% Mometasone Furoate Cream versus Twice-Daily 0.1% Betamethasone Valerate Cream in the Treatment of a Variety of Dermatoses

• Published in: Journal of international medical research Vol. 18; no. 6; pp. 460 - 467
• Main Authors: Viglioglia, P., Jones, M.L., Peets, E.A.
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.11.1990; Cambridge Medical Publications
• Subjects: Administration, Cutaneous; Adolescent; Adult; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - adverse effects; Betamethasone - administration & dosage; Betamethasone - adverse effects; Biological and medical sciences; Dermatitis, Atopic - drug therapy; Dermatitis, Contact - drug therapy; Drug Administration Schedule; Female; Glucocorticoids; Humans; Male; Medical sciences; Mometasone Furoate; Ointments; Pharmacology. Drug treatments; Pregnadienediols - administration & dosage; Pregnadienediols - adverse effects; Random Allocation; Skin, nail, hair, dermoskeleton; Mometasone furoate; atopic dermatitis; steroid-responsive dermatoses; allergic contact dermatitis; betamethasone valerate; Human; Allergy; Corticosteroid; Immunopathology; Skin disease; Cream; Dermatitis; Chemotherapy; Treatment; Contact dermatitis; Atopic dermatitis; Betamethasone; Comparative study; Topical administration
• ISSN: 0300-0605; 1473-2300
• DOI: 10.1177/030006059001800603

A randomized, investigator-blind, parallel-group trial was conducted to compare the safety and efficacy of 0.1% mometasone furoate cream applied once daily with that of 0.1% betamethasone valerate cream applied twice daily in patients (n = 69) with allergic contact dermatitis, atopic dermatitis and other steroid-responsive dermatoses. After 3 days' treatment improvement in conditions averaged 38.2 % and 39.3%, respectively, in the mometasone and betamethasone treatment groups, and after 21 days average improvements were 93.6% and 96.5%, respectively. The physicians' global evaluation of overall change in disease status and the patients' evaluation of treatment also indicated that the two treatment regimens produced comparable, rapid and progressive improvements in the patients' conditions, and no local side-effects were reported. It is concluded that mometasone furoate was as effective as betamethasone valerate in the treatment of a variety of steroid-responsive dermatoses, although mometasone furoate was applied only half as frequently.