Environmental amoebae and mycobacterial pathogenesis

• Published in: Methods in molecular biology (Clifton, N.J.) Vol. 465; p. 433
• Main Authors: Harriff, Melanie, Bermudez, Luiz E
• Format: Journal Article
• Language: English
• Published: United States 2009
• Subjects: Acanthamoeba - microbiology; Amoeba - microbiology; Gene Expression Regulation, Bacterial; Genes, Bacterial; Host-Pathogen Interactions; Humans; Macrophages - microbiology; Mycobacterium - genetics; Mycobacterium - pathogenicity; Mycobacterium avium - genetics; Mycobacterium avium - pathogenicity

Environmental amoebae have been shown to be a host to pathogenic mycobacteria. Mycobacterium avium, Mycobacterium marinum, and Mycobacterium peregrinum can all grow inside Acanthamoeba and other environmental amoebae. Once ingested by Acanthamoeba, M. avium upregulates a number of genes, many of the...