Environmental amoebae and mycobacterial pathogenesis
Environmental amoebae have been shown to be a host to pathogenic mycobacteria. Mycobacterium avium, Mycobacterium marinum, and Mycobacterium peregrinum can all grow inside Acanthamoeba and other environmental amoebae. Once ingested by Acanthamoeba, M. avium upregulates a number of genes, many of the...
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Published in | Methods in molecular biology (Clifton, N.J.) Vol. 465; p. 433 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
2009
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Abstract | Environmental amoebae have been shown to be a host to pathogenic mycobacteria. Mycobacterium avium, Mycobacterium marinum, and Mycobacterium peregrinum can all grow inside Acanthamoeba and other environmental amoebae. Once ingested by Acanthamoeba, M. avium upregulates a number of genes, many of them similar to genes upregulated upon phagocytosis of M. avium by macrophages. Mycobacteria ingested by amoebae grow intracellularly, acquiring an invasive phenotype, evident when the bacterium escapes the infected amoeba. Once inside of amoeba, it has been shown that mycobacteria are protected from antibiotics and disinfectants, such as chlorine. This chapter describes methods employed for the study of the interaction of M. avium and Acanthamoeba. |
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AbstractList | Environmental amoebae have been shown to be a host to pathogenic mycobacteria. Mycobacterium avium, Mycobacterium marinum, and Mycobacterium peregrinum can all grow inside Acanthamoeba and other environmental amoebae. Once ingested by Acanthamoeba, M. avium upregulates a number of genes, many of them similar to genes upregulated upon phagocytosis of M. avium by macrophages. Mycobacteria ingested by amoebae grow intracellularly, acquiring an invasive phenotype, evident when the bacterium escapes the infected amoeba. Once inside of amoeba, it has been shown that mycobacteria are protected from antibiotics and disinfectants, such as chlorine. This chapter describes methods employed for the study of the interaction of M. avium and Acanthamoeba. |
Author | Bermudez, Luiz E Harriff, Melanie |
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SubjectTerms | Acanthamoeba - microbiology Amoeba - microbiology Gene Expression Regulation, Bacterial Genes, Bacterial Host-Pathogen Interactions Humans Macrophages - microbiology Mycobacterium - genetics Mycobacterium - pathogenicity Mycobacterium avium - genetics Mycobacterium avium - pathogenicity |
Title | Environmental amoebae and mycobacterial pathogenesis |
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