Osteomyelitis and lung abscess due to Aspergillus fumigatus in a chronic granulomatous disease patient

Chronic granulomatous disease (CGD) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This disorder results in recurrent life-threatening bacterial and fungal infections. species are the most common fungal infections in these patients. Herein, we pr...

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Bibliographic Details
Published inCurrent medical mycology Vol. 2; no. 3; pp. 37 - 41
Main Authors Mamishi, S, Zomorodian, K, Saadat, F, Jalali, S Z, Geramishoar, M
Format Journal Article
LanguageEnglish
Published Iran Iranian Society of Medical Mycology 01.09.2016
Mazandaran University of Medical Sciences
Subjects
Antifungal agents
Aspergillus
Case Report
Chronic granulomatous disease
Aspergillus
Chronic granulomatous disease
Antifungal agents
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Summary:Chronic granulomatous disease (CGD) is an inherited disorder of the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex. This disorder results in recurrent life-threatening bacterial and fungal infections. species are the most common fungal infections in these patients. Herein, we present a case of fungal infection in a girl with CGD. We confirmed aspergillosis through the positive microscopic and macroscopic examinations, as well as radiology results. Invasive aspergillosis in this patient with pneumonia, lung abscess, and osteomyelitis of the ribs was not initially treated with amphotericin B (Am B) and recombinant interferon-gamma. Among infectious diseases, fungal infections, in particular aspergillosis, remain a serious problem in CGD patients. Considering poor clinical response and deficient immune system, rapid diagnosis of fungal infection and optimizing the treatment of these patients are recommended.
ISSN:2423-3439
2423-3420
DOI:10.18869/acadpub.cmm.2.3.37