Citrulline malate limits increase in muscle fatigue induced by bacterial endotoxins

Citrulline malate is known to improve performance in weakened muscles. The present experiment was designed to test the hypothesis that citrulline malate can limit the effect of endotoxins on muscle fatigability. Endotoxemia was induced in rats by injection of lipopolysaccharides from Klebsiella pneu...

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Bibliographic Details
Published inCanadian journal of physiology and pharmacology Vol. 75; no. 3; p. 205
Main Authors Goubel, F, Vanhoutte, C, Allaf, O, Verleye, M, Gillardin, J M
Format Journal Article
LanguageEnglish
Published Canada 01.03.1997
Subjects
Animals
Citrulline - analogs & derivatives
Citrulline - pharmacology
In Vitro Techniques
Klebsiella pneumoniae
Lipopolysaccharides - toxicity
Malates - pharmacology
Male
Muscle Fatigue - drug effects
Muscle Fatigue - physiology
Muscle, Skeletal - drug effects
Muscle, Skeletal - physiology
Rats
Rats, Wistar
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Summary:Citrulline malate is known to improve performance in weakened muscles. The present experiment was designed to test the hypothesis that citrulline malate can limit the effect of endotoxins on muscle fatigability. Endotoxemia was induced in rats by injection of lipopolysaccharides from Klebsiella pneumoniae. Resistance to fatigue was quantified by measuring tension production during repetitive electrical stimulation of the isolated epitrochlearis muscle. Oral treatment by citrulline malate was found to increase resistance to fatigue in infected rats, whereas twitch tension was not modified. This demonstrates the efficacy of citrulline malate for limiting an increase in muscle fatigue elicited with bacterial endotoxins.
ISSN:0008-4212
DOI:10.1139/Y97-029