TNF-α and chronic fatigue syndrome

Based upon the clinical presentation of chronic fatigue syndrome (CFS), we hypothesized that proinflammatory cytokines may play a role in the pathogenesis of the disease. We therefore undertook a retrospective cross-sectional study to examine the role of TNF-alpha in patients with CFS. Our results s...

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Bibliographic Details
Published inJournal of clinical immunology Vol. 19; no. 5; pp. 314 - 316
Main Authors MOSS, R. B, MERCANDETTI, A, VOJDANI, A
Format Journal Article
LanguageEnglish
Published New York, NY Kluwer/Plenum 01.09.1999
Subjects
Adult
Aged
Biological and medical sciences
Cross-Sectional Studies
Fatigue Syndrome, Chronic - blood
Fatigue Syndrome, Chronic - immunology
Female
Humans
Male
Medical sciences
Middle Aged
Nervous system involvement in other diseases. Miscellaneous
Neurology
Retrospective Studies
Tumor Necrosis Factor-alpha - metabolism
Human
Inflammation
Pathogenesis
Tumor necrosis factor α
Chronic fatigue syndrome
Cytokine
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Summary:Based upon the clinical presentation of chronic fatigue syndrome (CFS), we hypothesized that proinflammatory cytokines may play a role in the pathogenesis of the disease. We therefore undertook a retrospective cross-sectional study to examine the role of TNF-alpha in patients with CFS. Our results suggest a significant increase serum TNF-alpha in patients with CFS (P<0.0001) compared to non-CFS controls. This study supports the further examination of the role of proinflammatory mediators in CFS. Furthermore, the clinical testing of TNF-alpha blockers and other antiinflammatory agents for the treatment of this disease is warranted.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0271-9142
1573-2592
DOI:10.1023/A:1020595709352