Infectious Diseases Evaluation of the Child With Suspected Hemophagocytic Lymphohistiocytosis

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive and maladaptive inflammation. In this review, we discuss how the clinical and laboratory features of HLH overlap with infection and propose a diagnostic and treatment strategy to identify patients with infections mimicking HLH.

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Bibliographic Details
Published inJournal of the Pediatric Infectious Diseases Society Vol. 13; no. 3; pp. 220 - 227
Main Authors Deza Leon, Maria, Otto, William R, Danziger-Isakov, Lara, Kumar, Ashish, Scaggs Huang, Felicia
Format Journal Article
LanguageEnglish
Published US Oxford University Press 19.03.2024
Subjects
Child
Communicable Diseases
Humans
Lymphohistiocytosis, Hemophagocytic - diagnosis
hemophagocytosis
infection
cytokine storm
HLH
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Summary:Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive and maladaptive inflammation. In this review, we discuss how the clinical and laboratory features of HLH overlap with infection and propose a diagnostic and treatment strategy to identify patients with infections mimicking HLH.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:2048-7207
2048-7207
DOI:10.1093/jpids/piae007